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pharma news today obesity drugs glp-1 october 2025 Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity November 5, 2025 DOI: 10.1056/NEJMdo008238 New for the treatment of obesity - and so many additional indications being studied

Marsoni M251S
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4.4 ★★★★★
Based on 769 reviews
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Product Reviews
C
Verified Purchase
Cassandra Allen
Grantham, US
★★★★★ 5
Wonderful tool
Wonderful tool and works great
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 9, 2025
M
Verified Purchase
Mike M
Boise, US
★★★★★ 5
Nice upgrade 51mm for me
Color: Silver
This is my second 51mm machine. I never used the included handle or basket… I kept my existing HUGH IMS precision basket and bottomless portafilter. The temp and preinfusion are set and not adjustable but fine (reduced variables). I defeated the shut off by volume by setting higher than needed (wish that was easier to turn off). I like to manually shut off when I hit 30g on my scale. The machine will drip since there is not solenoid valve so I just pull the scale from the try when mouse tail breaks and drip starts. The steam wand and hot water dispenser is a massive upgrade (from Capresso EC50) and the real reason for my upgrade. I would have paid $50-100 more for the improvements listed… but I guess most people would not so this is about the best option for me with 51mm (keeping all the 51mm three lug portafilter stuff I own). 5 stars = for me and the price
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 18, 2026
A
Verified Purchase
angelo gaz
Fort Morgan, US
★★★★★ 5
Reliably makes a good cup of coffee!
Color: Rose Golden, Color: Rose Golden
This espresso machine is great. I wanted something simple and reliable and that’s exactly what it is. In fact, the espresso comes out with a nice creamy coffee froth on top and the flavor is excellent. I don’t normally write reviews, but I think this one is worth it and I want them to stay in business because I’ll probably be sending some of these out as gifts come next Christmas.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 1, 2026
W
Verified Purchase
walter Gmuer
San Leandro, US
★★★★★ 4
Easy to use
Color: Silver
Easy to use compact and easy to set up pulls some great espresso shots
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 24, 2026
C
Verified Purchase
Caroline Stephany
Waukegan, US
★★★★★ 5
Authentic
Color: Black, Color: Black
This machine is amazing. We just returned from Italy and this is as close to a cafe as you can get. It leaves a dense foam on top from the high pressure water system making truly authentic. It is easy to use and clean!! I loved the size too as it fits perfectly on our shelf. Highly recommend if you want an italian cafe to enjoy!
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Reviewed in the United States on February 4, 2026

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